{"id":1443,"date":"2020-10-30T07:26:28","date_gmt":"2020-10-30T13:26:28","guid":{"rendered":"https:\/\/cols.test\/?p=1443"},"modified":"2021-06-09T09:58:31","modified_gmt":"2021-06-09T15:58:31","slug":"dogs-and-human-aging-research","status":"publish","type":"post","link":"https:\/\/colostudy.org\/es\/perros-y-la-investigacion-del-envejecimiento-humano\/","title":{"rendered":"\u00bfLos perros nos hacen m\u00e1s saludables?"},"content":{"rendered":"

tienes un perro? Si es as\u00ed, probablemente haya experimentado beneficios positivos como un estilo de vida m\u00e1s activo y una mejor salud. A medida que envejece, un perro ayuda a reducir el aislamiento y la soledad, condiciones que lo exponen a un mayor riesgo de muerte prematura.<\/p>\n

Si bien los beneficios han sido bien documentados, no est\u00e1 claro qu\u00e9 sucede dentro de su cuerpo como resultado de tener un perro. Ahora, una asociaci\u00f3n \u00fanica de tres v\u00edas entre el Estudio Longitudinal de Colorado (COLS), un equipo de investigaci\u00f3n de la Universidad de Denver (DU) y una empresa de biotecnolog\u00eda de Boulder, ha desarrollado un estudio de investigaci\u00f3n para cuantificar y comprender los cambios biol\u00f3gicos que mantienen m\u00e1s sanos a los due\u00f1os de perros. que los que no tienen perros. Si la investigaci\u00f3n recibe financiaci\u00f3n, podr\u00eda conducir al desarrollo de terapias dirigidas a los mismos mecanismos para mejorar la salud en todas las personas con o sin perros.<\/p>\n

"Existe una amplia aceptaci\u00f3n de que los animales de compa\u00f1\u00eda mejoran las trayectorias de salud de sus due\u00f1os, pero los mecanismos subyacentes a esta observaci\u00f3n est\u00e1n mal definidos", dice Kevin Morris, PhD, director de investigaci\u00f3n del Instituto para la Conexi\u00f3n Humano-Animal (IHAC) de DU, quien liderar el estudio. "Al comprender las v\u00edas fisiol\u00f3gicas implicadas en los resultados de salud tanto de humanos como de perros, las interacciones entre personas y animales pueden optimizarse para mejorar la salud humana y esto podr\u00eda conducir al descubrimiento de nuevos objetivos farmacol\u00f3gicos basados en esa interacci\u00f3n natural".<\/p>\n

Una asociaci\u00f3n con sede en Colorado<\/h5>\n

Para el estudio, IHAC<\/a> se asociar\u00eda con COLS y SomaLogic, Inc., con sede en Boulder (SL<\/a>) para realizar una evaluaci\u00f3n de 5 a\u00f1os de 500 due\u00f1os de perros y un grupo de control de 500 personas que no tienen perros. La evaluaci\u00f3n recolectar\u00e1 sangre, orina y heces anualmente de los participantes, as\u00ed como informaci\u00f3n sobre estilo de vida y salud trimestralmente. Utilizando tecnolog\u00eda de \u00faltima generaci\u00f3n desarrollada por SL, el equipo de investigaci\u00f3n mapear\u00e1 m\u00e1s de 5.000 prote\u00ednas tanto en humanos como en perros. Estos mapas de prote\u00ednas, llamados perfiles prote\u00f3micos, reflejan cambios en tiempo real en la biolog\u00eda de una persona. A diferencia de muchos biobancos que se limitan a almacenar \u00fanicamente ADN, COLS utilizar\u00e1 tecnolog\u00eda avanzada para recolectar y almacenar muestras biol\u00f3gicas de una manera que preserve mol\u00e9culas fr\u00e1giles, como las prote\u00ednas, para permitir este tipo de investigaci\u00f3n.<\/p>\n

"La mayor\u00eda de las investigaciones actuales est\u00e1n limitadas por los datos disponibles en los biobancos actuales a observar la biolog\u00eda de una persona una vez que desarrolla una enfermedad o, a veces, antes de la enfermedad en personas que tienen una mutaci\u00f3n gen\u00e9tica que aumenta su riesgo de padecer una enfermedad en particular", dice Phyllis Wise, PhD, directora ejecutiva de COLS.\u00a0 <\/a>"Por el contrario, COLS recopilar\u00e1 datos sobre los participantes durante a\u00f1os antes del desarrollo de la enfermedad, lo que luego permitir\u00e1 a los investigadores mirar hacia atr\u00e1s en el tiempo para medir el impacto de un factor particular en la salud, en este caso tener un perro".<\/p>\n

Adem\u00e1s de investigar los cambios biol\u00f3gicos en los due\u00f1os de perros, el proyecto tambi\u00e9n estudiar\u00eda si los perros son centinelas de la salud y el envejecimiento humanos. "Debido a que los perros envejecen a un ritmo m\u00e1s r\u00e1pido que los humanos, se cree que la salud del perro podr\u00eda predecir la salud humana", dice Morris. "Si los perros desarrollan c\u00e1ncer en una comunidad a un ritmo m\u00e1s alto que el promedio, eso es potencialmente un indicador de que los humanos en esa comunidad tambi\u00e9n desarrollar\u00e1n c\u00e1ncer a un ritmo m\u00e1s alto".<\/p>\n

Este proyecto de investigaci\u00f3n es imposible sin las muestras biol\u00f3gicas y los datos de salud que recopilar\u00e1 COLS. Larry Oro<\/a>, PhD, profesor de biolog\u00eda molecular, celular y del desarrollo en la Universidad de Colorado Boulder y fundador de SL, fue el visionario detr\u00e1s de COLS. A lo largo de sus 40 a\u00f1os de carrera investigadora, Gold recorri\u00f3 los biobancos del mundo para encontrar muestras biol\u00f3gicas longitudinales de alta calidad, recolectadas y almacenadas antes y despu\u00e9s de la aparici\u00f3n de todas las enfermedades. Se dio cuenta de que el recurso que necesitaba no exist\u00eda, lo que le llev\u00f3 a su visi\u00f3n de COLS.<\/p>\n

Fort Collins ser\u00e1 el primer sitio de reclutamiento de COLS<\/h5>\n

COLS espera comenzar a reclutar participantes en el \u00e1rea de Fort Collins a fines de 2021. En esta primera fase, COLS reclutar\u00e1 a 16,000 habitantes de Colorado y comenzar\u00e1 a recolectar y almacenar sus muestras biol\u00f3gicas y datos sociol\u00f3gicos, ambientales y de salud durante cinco a\u00f1os. Despu\u00e9s del primer a\u00f1o, COLS comenzar\u00e1 a reclutar participantes adicionales en todo Colorado que representen la diversa geograf\u00eda, edades, niveles de ingresos, raza y g\u00e9nero del estado, y eventualmente crecer\u00e1 hasta recopilar datos sobre cientos de miles de participantes durante 10 a\u00f1os o m\u00e1s.<\/p>\n

"Tener este biobanco de muestras biol\u00f3gicas realmente completo y grande y todos los datos cl\u00ednicos y demogr\u00e1ficos asociados con esas muestras durante un largo per\u00edodo de tiempo para cada persona es un tesoro que los investigadores deben explorar", dice Morris. "Nuestro proyecto de prote\u00f3mica por s\u00ed solo muestra formas de proporcionar investigaciones realmente valiosas que no podr\u00edan realizarse con ning\u00fan otro biobanco existente".<\/p>\n

Las tres organizaciones detr\u00e1s de este proyecto est\u00e1n trabajando juntas para explorar oportunidades de financiaci\u00f3n de fil\u00e1ntropos individuales, fundaciones y agencias de financiaci\u00f3n estatales y federales. A nivel local, COLS actualmente est\u00e1 buscando donaciones individuales para apoyar la apertura de su primer sitio de participaci\u00f3n en Fort Collins, donde se reclutar\u00e1 a los participantes de la Fase I para este estudio.<\/p>\n

Si est\u00e1 interesado en el trabajo de COLS, considere hacer una donaci\u00f3n deducible de impuestos a COLS.\u00a0<\/strong><\/p>\n

Obtenga m\u00e1s informaci\u00f3n sobre formas de donar<\/a><\/p>\n

 <\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

\u00bfTienes perro? Si es as\u00ed, probablemente hayas experimentado sus beneficios, como un estilo de vida m\u00e1s activo y una mejor salud. A medida que envejecemos, un perro ayuda a reducir el aislamiento y la soledad, condiciones que aumentan el riesgo de muerte prematura. Si bien los beneficios est\u00e1n bien documentados, no est\u00e1 claro qu\u00e9 est\u00e1 sucediendo [\u2026]<\/p>","protected":false},"author":17,"featured_media":1456,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[28,29],"tags":[30,32,33,31,34],"class_list":["post-1443","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cols-research","category-fragile-molecules","tag-biobank","tag-companion-animals","tag-dogs","tag-proposed-research","tag-proteomic-profiles"],"yoast_head":"\nDo Dogs Make Us Healthier? - Colorado Longitudinal Study<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/colostudy.org\/es\/perros-y-la-investigacion-del-envejecimiento-humano\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Do Dogs Make Us Healthier? - Colorado Longitudinal Study\" \/>\n<meta property=\"og:description\" content=\"Do you own a dog? If so, you\u2019ve probably experienced the positive benefits like a more active lifestyle and better health. As you grow older, a dog helps reduce isolation and loneliness, conditions that put you at higher risk of early death. 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