Researchers are looking at the years and sometimes decades before patients are diagnosed with multiple sclerosis to find a biomarker that predicts the disease development. One area being researched is a marker in the blood called neurofilament light. How Early Does MS Begin, a blog post on Momentum, the blog for The National MS Society, describes this work. The vision for COLS is to create a “warehouse” of information that researchers could probe for these answers without having to create their own database.
View ArticleThe Health Impact of Wildfire Smoke
It is widely understood that wildfires cause an immediate spike in respiratory emergencies and heart attacks in nearby communities. But researchers are beginning to see that smoke inhalation from massive wildfires might have severe long-term health impact as well — and that people far away from the fires may be at even higher risk. Wildfire smoke is an especially dangerous form of pollution because it is filled with reactive chemical compounds that can be carcinogenic. These particles undergo oxidation as they are carried in the wind, converting them into highly reactive compounds the longer they are airborne. Just a few of the long-term impacts of wildfire smoke are thought to be increased incidence of respiratory illness, cancer, and the risk of premature births. Newborn babies could be at particular danger because their developing lungs are highly vulnerable to smoke toxicity. By collecting biological specimens over decades in time, biobanks such as COLS will help researchers identify track the changes that occur in people who are exposed to wildfire smoke, perhaps leading to early interventions that stop disease from progressing.
View ArticleGenetic Changes Preceding Alzheimer’s Could Lead to Preventive Therapies
Scientists have identified a series of changes in gene expression that appear to predict the onset of Alzheimer’s Disease. A team of researchers from the University of Pennsylvania studied changes in RNA, proteomic profiles, and epigenomics in postmortem brains to identify molecular pathways involved in the neurogenerative disease. Their results, published in the journal Nature Genetics, found that the development of Alzheimer’s involves a reconfiguration of the epigenome. The scientists suspect the discovery could lead to the development of epigenetic strategies for early-stage treatment or prevention of the neurogenerative disease.
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Biomarkers Improve Drug Approval Rates
Cancer drugs that use biomarkers to stratify patients during clinical trials obtain market approval at 5 times the average rate.
View ArticleUsing Proteins to Predict Complications
Proteomics and proteins can provide biomarkers to predict immunosuppressant toxicity and infection in renal transplant patients.
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