Can the flu, polio, chicken pox, or other vaccines lower a person’s risk of contracting COVID-19? It might seem far-fetched that a vaccine designed to protect against one infection could protect against others, too. But a growing body of research suggests that this does, in fact, occur through a process called “trained innate immunity.” Vaccines are known to work by stimulating the adaptive immune system, causing the body to make antibodies that can recognize and attack a specific pathogen if it is encountered again. But recent studies suggest that some vaccines also train the body’s faster-acting and less specific innate immune system, improving its ability to fight off many kinds of infections. Vaccines appear to achieve this feat by reprogramming stem cells that give rise to cells involved in this early innate immune response. Long-term studies across various populations are needed to understand if trained immunity is valid and whether it can be replicated for other coronaviruses.
View ArticleThe Health Impact of Wildfire Smoke
It is widely understood that wildfires cause an immediate spike in respiratory emergencies and heart attacks in nearby communities. But researchers are beginning to see that smoke inhalation from massive wildfires might have severe long-term health impact as well — and that people far away from the fires may be at even higher risk. Wildfire smoke is an especially dangerous form of pollution because it is filled with reactive chemical compounds that can be carcinogenic. These particles undergo oxidation as they are carried in the wind, converting them into highly reactive compounds the longer they are airborne. Just a few of the long-term impacts of wildfire smoke are thought to be increased incidence of respiratory illness, cancer, and the risk of premature births. Newborn babies could be at particular danger because their developing lungs are highly vulnerable to smoke toxicity. By collecting biological specimens over decades in time, biobanks such as COLS will help researchers identify track the changes that occur in people who are exposed to wildfire smoke, perhaps leading to early interventions that stop disease from progressing.
View Article